Validity and Repeatability Characteristics of a Non-Invasive, Infrared-Based Method Estimating Plasma Indocyanine Green Decay in Healthy Dogs

Validity and Repeatability Characteristics of a Non-Invasive, Infrared-Based Method Estimating Plasma Indocyanine Green Decay in Healthy Dogs

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Plasma clearance of indocyanine green (ICG-CL) is an invasive method to evaluate liver dysfunction.We aimed to investigate the practicality of a noninvasive, transcutaneous, infrared-based method estimating the disappearance rate of indocyanine green (ICG-PDR).In a randomized, cross-over study, both ICG-CL and ICG-PDR were determined in eight healthy dogs while conscious and when sedated with medetomidine and medetomidine–vatinoxan.

ICG-PDR was further repeated in six of the dogs to assess its repeatability.Differences were tested with repeated-measures analysis of variance and post hoc t-tests with Bonferroni ivoryjinelle.com corrections, while associations were evaluated by both Spearman and Pearson correlation analyses.Furthermore, repeatability was assessed by examining calculated coefficients of variation (CV).

A significant decrease in ICG-CL was observed in dogs sedated with medetomidine, while no difference between conscious and sedated states was detected with bekindtopets.com ICG-PDR.Overall, correlations between ICG-CL and ICG-PDR were poor, as was the intrasubject repeatability of ICG-PDR in conscious dogs with CV consistently above 20%.While some of the results may be explained by poor signal quality for the non-invasive method, we conclude that in healthy dogs ICG-PDR performed poorly.